Browsing by Author "Moon, R. C."
Now showing items 1-7 of 7
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Cancer chemopreventive activity of brassinin, a phytoalexin from cabbage
Mehta, R. G.; Liu, J.; Constantinou, Andreas I.; Thomas, C. F.; Hawthorne, M.; You, M.; Gerhäuser, C.; Pezzuto, J. M.; Moon, R. C.; Moriarty, R. M. (1995)Brassinin [3-(S-methyldithiocarbamoyl aminomethyl indole], a phytoalexin first identified as a constituent of cabbage, was synthesized and evaluated for cancer chemopreventive activity. Dose-dependent inhibition of ...
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Article
Dietary retinoids and carotenoids in rodent models of mammary tumorigenesis
Moon, R. C.; Constantinou, Andreas I. (1997)In this review of the scientific literature the relationship between retinoids, carotenoids, and mammary carcinogenesis is examined. Several retinoids have shown promise as chemopreventive agents against chemically induced ...
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Article
Distribution of epidermal growth factor receptors in normal and neoplastic mammary tissues
Mehta, R. G.; Mehta, R. R.; Constantinou, Andreas I.; Moon, R. C. (1995)Epidermal growth factor (EGF) is considered to be mitogenic for proliferation of mammary glands in animals. The action of EGF is mediated by specific EGF receptors (EGF-R). In the present study, we investigated distribution ...
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Erratum: Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase (Nature Medicine 1, 260-266, (1995))
Gerhauser, C.; Mar, W.; Lee, S. K.; Suh, N.; Luo, Y.; Kosmeder, J.; Luyengi, L.; Fong, H. H. S.; Kinghorn, A. D.; Moriarty, R. M.; Mehta, R. G.; Constantinou, Andreas I.; Moon, R. C.; Pezzuto, J. M. (1995)
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Article
Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase
Gerhäuser, C.; Mar, W.; Lee, S. K.; Suh, N.; Luo, Y.; Luyengi, L.; Fong, H. H. S.; Kinghorn, A. D.; Mehta, R. G.; Mar, W.; Mehta, R. G.; Constantinou, Andreas I.; Moon, R. C.; Pezzuto, J. M. (1995)For the discovery of new cancer chemopreventive agents, we have studied the potential of plant extracts to inhibit phorbol ester-induced ornithine decarboxylase (ODC) activity in cell culture. Four active rotenoids were ...
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Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylasetissue plasminogen activator-mediated thrombolysis
Gerhäuser, C.; Mar, W.; Lee, S. K.; Suh, N.; Luo, Y.; Kosmeder, J.; Luyengi, L.; Fong, H. H. S.; Kinghorn, A. D.; Moriarty, R. M.; Mehta, R. G.; Constantinou, Andreas I.; Moon, R. C.; Pezzuto, J. M. (1995)For the discovery of new cancer chemopreventive agents, we have studied the potential of plant extracts to inhibit phorbol ester-induced ornithine decarboxylase (ODC) activity in cell culture. Four active rotenoids were ...
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Article
Structure-activity relationships of brassinin in preventing the development of carcinogen-induced mammary lesions in organ culture
Mehta, R. G.; Liu, J.; Constantinou, Andreas I.; Hawthorne, M.; Pezzuto, J. M.; Moon, R. C.; Moriarty, R. M. (1994)Brassinin, a pkytoalexin, is found in Chinese cabbage. Previously, we showed that brassinin significantly inhibited dimethylbenz(a)anthracene (DMBA)-induced mammary lesions in organ culture. Moreover, it was an effective ...